AstraZeneca Extends Its Investment in Russia + Vacancies [1

[PCM] AstraZeneca Extends Its Investment in Russia + Vacancies [1 Attachment]

TO: recipients

CC: 2 recipients

Show Details

[Attachment(s) from Pharmacists_coffee included below]

- To stop receiving newsletter, reply with "Stop"

- To subscribe to PCM newsletter click here

- To publish vacancy please click here

Home : Archive : Subscribe : Contact us : Upload CV : Invite friends : Publish Vacancy

Pharmacists_ coffee magazineElectronic Edition
Edition No. 410, year 4June 17, 2011
Today's edition sent to: 24,365 Arabian Pharmacists

Find Valuable attachment"OrganicaANDBioChemistry"
may find attachment at the end of e-mail

Today in Hot pharma news

Medicine of the week

Alprazolam

Alprazolam (trade name Xanax, among others) is a potent short-acting drug of the benzodiazepine class. It is primarily used to treat moderate to severe anxiety disorders (e.g., social anxiety disorder) and panic attacks, and is used as an adjunctive treatment for anxiety associated with moderate depression. It is available in an instant release and an extended-release (Xanax XR) preparation, both of which are available under several generic names. Alprazolam possesses anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant properties.^[3]
Alprazolam has a fast onset of symptom relief (within the first week). It is the most commonly misused benzodiazepine; however, the majority of prescribed users do not develop a substance use disorder.^[4][5] Tolerance to the therapeutic effects of alprazolam is controversial with one view being that alprazolam is ineffective with long term use^[6] and the other view being that tolerance to the therapeutic effects does not occur.^[7] A physical dependence commonly occurs as a result of alprazolam treatment, typified by a withdrawal and rebound symptoms necessitating a gradual reduction in dosage to minimize withdrawal effects when discontinuing.^[4] Withdrawal symptoms similar in character to those noted with sedative-hypnotics such as alcohol have occurred following discontinuance of benzodiazepines, including alprazolam. The symptoms can range from mild dysphoria and insomnia to a major syndrome that may include anxiety, abdominal pain, muscle cramps, vomiting, depression, sweating, tremors and in rare cases seizures, suicidal ideation or suicide itself.^[8]

Indications:

The main medical uses for

alprazolam include:

Panic disorder

Alprazolam is FDA-approved for the short-term treatment (up to 8 weeks) of panic disorder, with or without agoraphobia. Alprazolam is very effective in the short-term symptomatic relief of moderate to severe anxiety, essential tremor, and panic attacks. Physicians that elect to prescribe alprazolam for longer than 8 weeks should be aware that continued efficacy has not been systematically demonstrated beyond 8 weeks' use, as tolerance to alprazolam's effects may occur after 8 weeks and necessitate discontinuation or physician-directed dose escalation.^[15] The physician should periodically reassess the usefulness of the drug for the individual patient.^[16] Alprazolam is recommended for treatment resistant cases of panic disorder where there is no history of tolerance or dependence.^[17]

Anxiety disorders

Alprazolam is indicated for the management of anxiety disorders (a condition corresponding most closely to the APA Diagnostic and Statistical Manual DSM-III-R diagnosis of generalized anxiety disorder) or the short-term relief of symptoms of anxiety.^[16] Alprazolam is recommended for the short-term treatment (2–4 weeks) of severe acute anxiety.^[18][19]
Alprazolam is sometimes prescribed for anxiety with associated depression. There is some evidence that it has antidepressant effects in treating clinical depression in outpatient settings; evidence for inpatients is lacking.^[20] The antidepressant effects of alprazolam may be due to its effects on beta-adrenergic receptors.^[21] Other benzodiazepines are not known to have antidepressant activity.^[22][23] Studies show that any antidepressant action of alprazolam is questionable and generally weak in comparison to those of antidepressant medications.^{[24][25][26][27]} In contrast, while alprazolam in acute or short-term treatment may have some antidepressant properties, there is evidence that up to a third of long-term users of alprazolam may develop depression.^[28]

KSA to KSA

+ Add a vacancy

Sales Representative

In Jeddah, Riyadh & Dammam

The Arab company for pharmaceutical products” Arabio”

is the first Arabian company in the region specialized in biological products & vaccines.

We are looking to recruit high caliber, smart& committed sales representatives

for our organization in all Saudi Arabia.

Requirements:

1. B.Sc science or any bachelor degree from reputable university.

2. Experience at least 2-3 years of hands on experience in Saudi Arabia.

3. Language: English& Arabic speaking.

4. Skill& Attitude: we are looking for smart, honest, hard working, has ability to work within team, dependable, self motivated and has ability to learn and grow his career.

5. Must have transferable Iqama, valid driving license.

If you are up to this challenge and have the willing & the motive to build your career and develop yourself, please apply with your CV including clear experiences and personal clear photo to the following e-mail:

Search This Blog

Search The Web

Friday, June 17, 2011